Endocrine Abstracts

Introduction: Prior to 2015 there was no pathway for adrenal masses. An Adrenal MDT was started to discuss all the adrenal nodules (except for suspected phaechromocytoma and adrenal carcinoma) to improve the service for this cohort of patients. This audit is a review of the impact of this intervention.Methods: Data was collected between April 2016 and March 2016 for all adrenalectomies performed at East Sussex Hospitals Trust. Data was collected from the...

A 45-year old lady admitted to hospital in October 2018 with generally unwell and nausea. She has a background of disseminated T.B. confirmed by EBUS with bronchoalveolar lavage in September 2018. She had previous CT thorax, abdomen and pelvis in September 2018 which was reported as extensive lymphadenopathy with omental and peritoneal thickening. She also has a history of vitamin D deficiency in August 2018 at 7.1 nmol/l and was treated with oral colecalciferol. The biochemic...

Diabetes is a common presentation in children and young people. We describe a case of undiagnosed cystic fibrosis (CF), where diabetes was the presenting diagnosis. A 14 year old girl presented with a 2-month history of weight loss, abdominal pain, polyuria and polydipsia. Blood glucose was 31.4 mmol/l with ketones of 0.8 mmol/l, and a diagnosis of T1DM was made. Initial bloods showed HbA1c 150 mmol/mol, normal thyroid function, negative TTG, and negative TPO, GAD and IA2 anti...

Case history: Two Syrian refugee siblings aged 21 and 20 years, were referred. Ambiguous genitalia had been identified at birth and had been raised as males. They wished a more masculine habitus and had concerns regarding their fertility. The elder sibling had ambiguous genitalia at birth and a 46,XX karyotype. Long-term steroid treatment had been initiated and corrective genital surgery performed at 9 months of age. For unknown reasons, steroids were stopped after 9 years. He...

A 26-year-old Chinese male with autism spectrum disorder and mental retardation, was referred to start insulin therapy for uncontrolled diabetes mellitus (DM) (HbA1c: 9%; C-peptide: 1.75 ng/ml; anti-GAD AB: negative) treated with oral antidiabetic drugs since 2012.Clinical examination revealed a tall man with overweight and truncal obesity in light of his ethnicity. We withheld facial dysmorphism with hypertelorism, scarce facial hair, and clinodactyly. ...

Endocrine disrupting chemicals (EDCs) are exogenous compounds that affect the endocrine system, disrupt the hormonal balance and consequently cause the adverse health effects in humans. These compounds persist and accumulate in the environment and can easily gain entry to the food chain. Peroxisome proliferator-activated receptor gamma (PPARγ) and its heterodimeric partner retinoid X receptor alpha (RXRα) are very often targets of EDCs. PPARγ play crucial role i...

Background: People with intellectual disability (ID) are living longer and more likely to develop Type 2 diabetes (T2D). It is recognised in many westernised countries that better self-management of T2D can improve the persons’ health and quality of life: one such programme is DESMOND. However, such programmes have not been adapted for adults with ID.Objective: This poster focuses upon adapting DESMOND. There were two objectives, firstly, to explore...

Background: Between 1–2% of the population have an intellectual disability (ID), within this group the rate of diabetes is approximately 12%: three times higher than the non-disabled population. Although pharmacological therapy is frequently prescribed for this population, there is a lack of evidence underpinning these interventions. Likewise, there is a paucity of evidence regarding the different behavioural self-management programmes for people with ID.<p class="abs...

Introduction: Primary hyperaldosteronism is still an underdiagnosed cause of hypertension. The challenge lies however, not only in diagnosing the primary hyperaldosteronism, but also in the distinction between aldosterone-producing adenoma (APA) and idiopathic adrenal hyperplasia (IHA). Establishing the correct diagnosis is after all essential, because surgery is only effective in patients with adrenal adenoma.Case report: We report about a 67-year-old p...

Anthocyanidins are aglycons of anthocyanins, which are plant pigments responsible for floral and fruits color. Anthocyanidins possess beneficial pharmacological properties such as antioxidant, anti-inflammatory, anti-tumor and anti-diabetic. Anthocyanidins are contained in normal diet and might play role in food-drug interactions.The aim of current study was to evaluate the effects of cyanidin, delphinidin, malvidin, pelargonidin and peonidin on the tran...